The results showed that the protein level of ESR1 in Grade 1 endometrial cancer tumor samples was significantly higher compared to Grade 2 and 3 samples (Fig. 1A), which was consistent with the trend of ESR1 protein content in sample lysates detected by western blot, indicating higher levels of ESR1 protein in Grade 1 endometrial tumor samples (Fig. 1B). Here, ESR1 is linked to endometrium neoplasm.