Jin et al. found that FTX activated FOXA2 expression to inhibit proliferation and migration of non-small-cell lung cancer (NSCLC) [23], while Huo et al. found that FTX promoted proliferation and migration of lung adenocarcinoma cells by targeting miR- 335 - 3p/NUCB2 axis [24], yet FTX has not been studied in islet cells. Here, NUCB2 is linked to lung adenocarcinoma.