Since the T allele of ERCC1 c.354C>T [52], A of MLH1 c.93G>A [53] and G of MSH3 c.3133A>G [55] were associated with lower DNA repair capacity, the association of these genotypes with CDDP‐induced nephrotoxicity in HNSCC patients is biologically plausible. This evidence concerns the gene MLH1 and head and neck squamous cell carcinoma.