Through LASSO regression analysis, GIPR (LASSO coefficient=0.2062), HGF (LASSO coefficient=−0.1533) and SNX10 (LASSO coefficient=0.0945) were confirmed as hub genes within B-ALL protein network (Fig. 1B and C), indicating their potential regulatory and functional significance in B-ALL biology. Here, HGF is linked to acute lymphoblastic leukemia.