By analyzing the GSE227832 dataset in combination with the TARGET-ALL-P3 dataset [from The Cancer Genome Atlas (TCGA)] including clinical data from 79 patients, three core hub genes closely associated with the progression of B-ALL were identified: Glucose-dependent insulinotropic polypeptide receptor (GIPR), hepatocyte growth factor (HGF) and sorting nexin 10 (SNX10). Here, GIPR is linked to precursor B-cell acute lymphoblastic leukemia.