This leads to the activation of EMT-associated signaling pathways that stimulate the expression of Twist and Snail, Slug, ZEB1/2, TGF-β, Wnt, and Notch, decreasing the expression of E-cadherin and vimentin, fibronectin, leading to tumor invasiveness and growth along with metastasis capabilities (Montemagno and Pages 2020). Here, TGFB1 is linked to neoplasm.