KDR and nervous system disorder: However, in a pathological state, an aberration in the VEGFR-2 functioning leads to the dysregulation of the angiogenic switch, causing the onset of different pathological conditions such as cancer (Eelen et al. 2020), inflammation (Szade et al. 2015), blood vessel diseases (Salven et al. 2002), and neurological disorders (Shim and Madsen 2018).