BDNF and attention deficit-hyperactivity disorder: 2019). Clinical studies have reported the improving effects of RIT on BDNF plasma concentrations in children with attention deficit hyperactivity disorder (ADHD) (Amiri et al. 2013). RIT might also impact neuronal survival by modulating apoptosis. It is able to modulate apoptosis‐related proteins, including apoptosis regulator Bcl‐2 (BCL2), BAX (BAX), and caspase‐3 (CASP3) (Réus et al. 2014). RIT indirectly activates dopamine postsynaptic receptors (Ko et al. 2019) that uptake dopamine and transmit the signal in postsynaptic neurons (Gronier 2011).