It has been reported that USP22 promotes cancer cell growth by deubiquitinating cyclin B1,16 proto‐oncogene MYC (c‐Myc)17 and far upstream element binding protein 1 (FBP1),18 while inhibiting apoptosis by deubiquitinating sirtuin 1 (Sirt1).19 Here, USP22 is linked to cancer.