This analysis revealed that resistant cells upregulated transcription factors downstream of the ERBB signaling pathway including AP-1 components, FOS, FOSB, JUN, and JUND, and also SOX9 and EHF; all of which are known promoters of cancer proliferation (Wee and Wang, 2017; LaMuraglia et al, 1988). This evidence concerns the gene EGFR and cancer.