AQP3 and melanoma: This alteration prevents normal osmotic regulation in cells, potentially impacting metabolic and homeostatic functions.[50] This study was further expanded by Da Silva et al. who examined AQP3 inhibition in melanoma cells, where three different gold compounds [Au(CCON)Cl2], [Au(CCH2N)Cl2] and [Au(CNHN)Cl2] (Figure 1) impaired H2O2 transport, disrupting cellular redox balance and ultimately inhibiting cancer cell adhesion, proliferation, and migration.[51] AQP3, a known peroxiporin, facilitates hydrogen peroxide diffusion across membranes and is frequently overexpressed in melanoma cells.