In this study, we found that several immune cell infiltration levels (B cells and macrophages) were correlated with TPD52 gene copy numbers in PRAD, and TPD52 expression was significantly correlated with tumor purity, but significantly positively correlated with infiltration levels of B cells, and CD8 + T cells in PRAD by using TIMER. This evidence concerns the gene CD8A and prostate adenocarcinoma.