BCL6 and diffuse large B-cell lymphoma: BCL6 (B-cell lymphoma 6) is a transcriptional repressor that plays a crucial role in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies40 As a master regulator of germinal center (GC) B-cell development, BCL6 facilitates the physiological genomic instability required for antibody affinity maturation40.