With the 15-state annotation of myometrium and ULs, we confirmed the finding for MED12 and HMGA2 groups, and could pinpoint in FH tumors that the hypermethylated regions annotated as other active chromatin in the 5-state model were in fact enhancers in the 15-state model (Fig. 2b). The gene discussed is HMGA2; the disease is familial hyperaldosteronism.