VTCN1 and neoplasm: In support of this possibility, knocking down ZDHHC3 (shZdhhc3) in 4H11 cells failed to alter tumor cell proliferation in vitro (Supplementary Fig. 3g), but reduced B7-H4 expression, and inhibited tumor growth in immune-competent mice (Fig. 3i–k and Supplementary Fig. 3h).