We also disrupted the H3K4me3 demethylase Kdm5c to investigate the role of H3K4me3 in AML cell proliferation, which showed tumor suppressor activity in our CRISPR assays (Figs. 1A, 7A, B, Supplementary Figs. 1F, 4A). Here, KDM5C is linked to acute myeloid leukemia.