TNFRSF1A and cancer: The possible mechanism includes binding to cellular TNF-α receptor 1 (TNFR1), which causes cancer cells to undergo apoptosis by activating reactive oxygen species (ROS) and releasing Cyt-C from mitochondria, or by attracting TNFR-associated death domain (TRADD) and Fas-associated protein with death domain (FADD)173–176.