CASP3 and neoplasm: It worth to mention that although caspase-3 is a cytosolic protein that mediates apoptosis in caco-2 cells, it would be better to measure the proteolytic change in caspase-3 and other key apoptotic mediators in the future as a reflection for signal transduction that ultimately leads to apoptosis156and as a prognostic biomarker for tumor stages and cell differentiation status following combination treatment157.