Correspondingly, another TBK1/IKKε inhibitor BX795 was shown by us to downregulate type I IFN production induced by Imiquimod, as well as spontaneous transcription of type I IFN stimulated genes IFI44, IFI44L, IFIT1, IFIT3 and MX1 in PBMCs from patients with SLE, pSjD and SSc.20 The gene discussed is TBK1; the disease is systemic sclerosis.