PDHA1 and neoplasm: DLD, PDHA1, and PDHB, as crucial subunits of the PDC, play significant roles in the process of cuproptosis.345,367 According to a study by Ma et al., the expression levels of DLD, PDHA1, and PDHB1 are notably higher than those of other CRGs in almost all tumors according to the TCGA database.368 Furthermore, the expression levels of these genes are also considered to be associated with tumor prognosis.