METTL16 and gastric neoplasm: In contrast, SIRT2, a classical deacetylase, significantly inhibits the lactylation of METTL16 and the m6A modification of FDX1, thereby impeding cuproptosis.295 Consistently, AGK2, a SIRT2-specific inhibitor, promotes the therapeutic effects of ES by inducing the lactylation of METTL16-mediated cuproptosis in gastric tumors in vitro and in vivo.