Liu et al. uncovered the abnormal activation of the Wnt/β-catenin signaling pathway imparts resistance to cuproptosis in tumor cells, proposing a precision medicine strategy for cancer treatment through the selective induction of cuproptosis.296 In the same year, Li et al. demonstrated that zinc transporter 1 (ZnT1) is a novel copper transport protein capable of mediating copper (II) uptake and inducing cuproptosis.297 Collectively, these studies contribute to a deeper understanding of the mechanisms and regulation of cuproptosis, highlighting its significance for therapeutic interventions. The gene discussed is SLC30A1; the disease is neoplasm.