TARDBP and amyotrophic lateral sclerosis: Of the 64 potential TDP-43 phosphorylation sites, 27 have been detected in ALS or FTLD-TDP via mass spectrometry approaches, with six major pathological sites recognised: S369, S379, S403/404, and S409/410 [11–13, 52, 75–77] (Fig. 1B).