CDC7 and early-onset autosomal dominant Alzheimer disease: Similarly, TDP-43 mislocalisation was decreased by CK1 or TTBK1 inhibition in Alzheimer’s disease patient-derived lymphoblasts, CK1 inhibition in ALS patient-derived lymphoblasts, CDC7 inhibition in ethacrynic acid treated SH-SY5Y cells, and CDC7 inhibition in FTD and ALS patient-derived lymphoblasts, [23, 24, 26, 27].