Among 61 patients with non-ccRCC, the detailed histopathological classification is as follows: 27 cases of Papillary RCC, 10 cases of Chromophobe RCC, 5 cases of Clear cell papillary RCC, 9 cases of RCC Associated with Xp11.2 Translocation/TFE3 Gene Fusion, 2 cases of Sarcomatoid RCC, 1 case of Collecting duct RCC, and 7 cases of Unclassified RCC.The ccRCC group exhibited higher PFA (p = 0.007), cPFA (p = 0.01), weight (p = 0.002), BMI (p < 0.001), and incidence of T1 stage (p = 0.01). The gene discussed is TFE3; the disease is renal cell carcinoma.