CADM2 and obesity due to melanocortin 4 receptor deficiency: CADM2 encodes a cell adhesion molecule and has been associated with impulsivity and risky behaviors (e.g. substance use; Sanchez-Roige et al., 2023), while the FTO gene has been implicated in obesity (Huang, Chen, & Wang, 2023) and substance use (Hatoum et al., 2023; Kember et al., 2023).