To further substantiate these results, we performed a meta-analysis of 3309 RA patients and observed that smoking was again predominantly associated with the combined presence of ACPA-IgA in addition to ACPA-IgG (OR 2.05 [1.69–2.49], p < 0.001) versus the single presence of ACPA-IgG (OR 1.18 [0.97–1.44], p = 0.11). The gene discussed is PRTN3; the disease is rheumatoid arthritis.