Recent research indicates that the suppression of Angptl4 results in a dose-dependent elimination of epithelial-mesenchymal transition (EMT)-mediated chemoresistance and tumor self-organization in three-dimensional (3D) cultures, ultimately leading to reduced metastatic potential and impaired growth of tumor xenografts (Liao et al. 2024), which consistent with our findings that C2 phenotype showed higher enrichment of EMT (Figure S1 F). Here, ANGPTL4 is linked to neoplasm.