These potentially novel driver genes (CCDC47, GFM2, IRF2BP1, LRRC10B, MICU3, MTCL1, OR51B2, PCDHAC2, PRUNE2, RDX, THBS3, URB2, and ZMYM6) currently have minimal literature describing their relevance in HCC and therefore warrant further investigation. The gene discussed is PRUNE2; the disease is hepatocellular carcinoma.