TP53 and cancer: Pathways enriched for genes with identified somatic variants (Additional file 1: Table S7) included molecular mechanisms of cancer (893 variant effects across 335 genes), hepatic fibrosis signaling (435 variant effects across 170 genes), ATM Signaling (134 variant effects across 46 genes; Additional File 2: Fig. S1), p53 Signaling (125 variant effects across 40 genes; Additional File 2: Fig. S2), and WNT/β-catenin signaling (198 variant effects across 69 genes; Additional File 2: Fig. S3).