DBF4 and hepatocellular carcinoma: Examples of genes with these high impact variants include ATAD2 [25], BCL9  [26], CP [27], DBF4 [28], DTNA [29], FGF23 [30], IFIT1  [31], MSRB1 [32], NID1 [33], NSUN5 [34], QRICH1 [35], TP53BP1  [36], and ZWINT [37] (Table 8; Additional file 1: Tables S4–S5) which have been previously linked to HCC proliferation and progression.