ACOT4 and obesity due to melanocortin 4 receptor deficiency: Novel high impact variants resulting in premature stop codons were identified in the following genes associated with enriched obesity pathways in Meishan pigs: PLIN1 (adipogenesis, white adipose tissue browning), GRB10 (insulin receptor signaling), and ACOT4 (stearate biosynthesis I) (Table 5).