Other genes harboring high impact variants with increased VAFs in the in vivo Oncopig HCC tumor compared to the Oncopig HCC cell line include CCDC47, GFM2, IRF2BP1, LRRC10B, MICU3, MTCL1, OR51B2, PCDHAC2, PRUNE2, RDX, THBS3, URB2, and ZMYM6 genes (Table 8). Here, IRF2BP1 is linked to hepatocellular carcinoma.