In 10/129 patients, we found germline variants in general cancer predisposition genes including CHEK2, BLM, BRCA2, CDKN2A, STK11, and candidate cancer predisposition genes, FMN2 and PIK3C3. Four patients harbored heterozygous CHEK2 germline alterations, R562Q and I157T and twice T367Mfs*15. Here, FMN2 is linked to cancer.