The pathophysiological process of AD is complex and is characterized by the abnormal processing of amyloid-β protein precursor, leading to the formation of amyloidogenic Aβ peptides that aggregate into neuritic plaques, and the presence of intracellular neurofibrillary tangles composed of a hyperphosphorylated form of the microtubule-associated protein tau, which contribute to neurodegeneration and cognitive decline.3, , , –7. The gene discussed is MAPT; the disease is Alzheimer disease.