KDM6B and cancer: In the realm of epigenetics, KDM6B stands out as a histone demethylase that is integral to the demethylation of H3K27me3.33 Its dysregulated expression is observed across various types of cancer, with varying implications for the biological behavior of tumors and their clinical outcomes.34–36 The diverse manifestations of KDM6B’s role underscore the complexity of its influence in the cancerous process.37