Takinginto account the emerging need to study unique metaboliccharacteristics of specific molecular subtypes of leukemia, we hypothesizethat RS can be used for the identification of B-ALL cells with HDand their differentiation from normal B cells and other selected molecularsubtypes of leukemia (hypodiploidy, TCF3-PBX1, KMT2A-r, BCR-ABL1,ZNF384, and TEL-AML1). This evidence concerns the gene TCF3 and leukemia.