In Italy as elsewhere, the risk of developing a breast recurrence varied, depending on the characteristics of the patients (i.e., recurrence 2 times more frequent for women younger than 40 years, compared to later ages) and of the tumours (i.e., 3 times higher probability of recurrence in those with stage III BC vs stage I, or 1.5 times higher if the tumour was TN vs HR+/HER2-). The gene discussed is ERBB2; the disease is breast cancer.