Another mechanism pointed to increased levels of the amyloid precursor protein (APP) beta‐C‐terminal fragment (β‐CTF) interacting with the APPL1 (the adaptor protein containing a pleckstrinhomology [PH] domain, phosphotyrosine binding [PTB] domain, and leucine zipper motif 1) scaffolding protein to increase RAB5 binding and activity on EEs in sporadic AD, familial AD (FAD), or DS‐AD.15, 16, 17, 18, 19. The gene discussed is APP; the disease is Alzheimer disease.