The levels of RAB3 GEF (MADD) and GAPs (Rab3GAP1 and Rab3GAP2)9 were significantly elevated in male controls, with no significant differences in the MADD/Rab3GAP1 ratio between DS‐AD and controls (Figure 2A,M–P). The gene discussed is RAB3GAP2; the disease is Alzheimer disease.