The genes CLUS, CERU, APOE, APOA4, APOA1, GELS, S10A9, AMBP, ACTB, CATA, and AFAM have been identified as important factors in leukemia prognosis, with the potential to act as unique biomarkers for gauging the aggressiveness of leukemia or as suppressor proteins specifically in cases of high-risk acute lymphoblastic leukemia (HR-ALL), as suggested by the study referenced as [52]. The gene discussed is APOE; the disease is leukemia.