Furthermore, the suppression of ACTB and the molecular interactions involving pairs such as “HBA1&HBB", ”HBB&HBA1", “IGKV1-5&IGHV4-31", “IGHV4-31&IGKV1-5", “HLA-DRA&CD74", and “A CTB&ACTB" might provide essential insights into unraveling the intricate mechanisms of acute leukemia. The gene discussed is IGKV1-5; the disease is acute leukemia.