The observed asthma-like presentation in children without a prior asthma diagnosis is consistent with previous epidemiologic reports,6 and translational evidence that EV-D68 may be associated with interleukin-17–dependent airway inflammation and hyperresponsiveness.37 Longitudinal follow up of children with EV-D68–associated illness is needed to better understand if children with an asthma-like presentation subsequently receive a formal diagnosis of asthma, or if these presentations are transient. The gene discussed is IL17A; the disease is asthma.