This retrospective, multicenter case series analysis combines 18 cases from our clinical practice with an additional 19 cases from the literature, providing a cohort of 37 benign, intermediate, and malignant HMGA2-altered salivary gland neoplasms analyzed for MDM2. We found an MDM2 amplification in 27% of the PA, as opposed to 78% of the CXPA (p-value 0.003). This evidence concerns the gene HMGA2 and salivary gland neoplasm.