Similarly, secretion of another NLRP3 inflammasome-dependent cytokine, IL-1β, was notably elevated in the IHGK cells (P < 0.01; Fig. 2E) and HSC-3 cells (P < 0.001; Fig. 2F), while SCC-24 A and −24B cancer cell lines showed negligible IL-1β response (P > 0.05; Supplementary Fig. 1). This evidence concerns the gene NLRP3 and cancer.