TGFB2 and central nervous system cancer: Given the prognostic impact of MGMT gene methylation and TGFB2 mRNA expression levels in pediatric diffuse midline gliomas [11,12] and low-grade glioma patients [7], we extended this study using a similar bioinformatic-led approach to elucidate the prognostic impact of TGFB2 and MGMT gene methylation and to characterize their effect on overall survival (OS) in adult GBM patients.