Given the prognostic impact of MGMT gene methylation and TGFB2 mRNA expression levels in pediatric diffuse midline gliomas [11,12] and low-grade glioma patients [7], we extended this study using a similar bioinformatic-led approach to elucidate the prognostic impact of TGFB2 and MGMT gene methylation and to characterize their effect on overall survival (OS) in adult GBM patients. Here, MGMT is linked to central nervous system cancer.