Kaplan–Meier analysis of the GBM patients stratified by methylation load and mRNA expression (Figure 5B–D) showed significant improvements in survival times for the patients expressing high levels of HIF1A, TRIM22, and PARP9 mRNA and a high methylation load, confirming the results obtained from the Cox proportional hazards models. This evidence concerns the gene PARP9 and glioblastoma.