The multivariate Cox regression models showed the improved OS impact of high levels of TGFB2 methylation for both the male and female patients, with minimal sexual dimorphism in the young GBM patients; we examined Reactome pathways that showed consistent enrichment of negatively correlated mRNA expression for genes across old, young, and all GBM patients (Figure 3, Table S1). The gene discussed is TGFB2; the disease is glioblastoma.