TRIM5 mRNA also predicted a prognostic impact in which significant impacts were observed for TGFB2 methylation, MGMT methylation, and the age by sex interaction, suggesting that high levels of TRIM5 mRNA, MGMT methylation, and TGFB2 methylation levels can be used as positive prognostic indicators for GBM patients. The gene discussed is TRIM5; the disease is glioblastoma.