Due to the complex nature of TGFB2 methylation in subsets of GBM patients and survival, we used the multivariate model to further substantiate the impact of TGFB2 as an independent variable considering the correlation with other variables, including age, sex, and methylation of TGFB1/3 and MGMT methylation. The gene discussed is TGFB2; the disease is glioblastoma.