Since the multivariate Cox proportional hazards model suggested independent effects of TGFB2 and MGMT methylation, we examined Reactomes that showed differential enrichment in the mRNA expression of genes correlated with MGMT compared to TGFB2 methylation (Figure S6, Table S4) for GBM patients and subsets stratified according to sex (all patients (N = 101), male (N = 59), and female (N = 42)). Here, MGMT is linked to glioblastoma.