Overall, TSP-1 works in a paracrine fashion to limit the extent and/or duration of inflammation during the host response to lung injury [38,39], which may play an important role in alveolar epithelial cell regeneration following respiratory distress syndrome and may be a critical target for the diagnosis and therapeutics of BPD (Figure 2). The gene discussed is THBS1; the disease is bronchopulmonary dysplasia.