SETDB1 and myalgic encephalomeyelitis/chronic fatigue syndrome: Furthermore, HERV upregulated in ME/CFS were markedly enriched in chromatin remodeling factor binding sites, including SETDB1 and TRIM28, both being key epigenetic repressors of HERV expression, pointing to the impairment of TRIM28/SETDB1 axis as the underlying mechanism of HERV upregulation in ME/CFS.