It is worth mentioning that HERV upregulated in ME/CFS (Module 3) were markedly enriched with binding sites for chromatin remodeling factors, from which SETDB1 and TRIM28 stand out as key epigenetic repressors of HERV expression and CTCF for its importance in the establishment of topologically associating domains in chromosomes. The gene discussed is SETDB1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.