In another study, adenovirus‐mediated IL‐24 overexpression in subcutaneous tumors generated using A549 and H1299 lung cancer cells resulted in significant tumor growth inhibition (40% in A549 and 27% in H1299) through the induction of apoptosis, via modulating CD31/PECAM expression and upregulating APO2/TRAIL (Saeki et al. 2002). Here, PECAM1 is linked to neoplasm.