CXCR4 and lung carcinoma: This decrease in CXCR4 levels was achieved by influencing downstream signaling through the AKT/mTOR signaling pathway (specifically pAKTS473, p‐mTORS2448, pPRAS40T246, and HIF‐1α), which subsequently contributed to decrease in lung cancer cell migration and invasion (Panneerselvam, Jin, et al. 2015).