This decrease in CXCR4 levels was achieved by influencing downstream signaling through the AKT/mTOR signaling pathway (specifically pAKTS473, p‐mTORS2448, pPRAS40T246, and HIF‐1α), which subsequently contributed to decrease in lung cancer cell migration and invasion (Panneerselvam, Jin, et al. 2015). Here, CXCR4 is linked to lung cancer.