Similarly, c-Myc and Mcl-1 responses to glutamine and QARS were observed in LOVO and SW1116 colorectal cancer cells harboring Gln-K604-intact FBW7 point mutations (Fig. 7C and 7D), suggesting that the loss of Gln-K604 contributes to the upregulation of c-Myc and Mcl-1 expression. Here, FBXW7 is linked to colorectal cancer.