FBXW7 and cancer: Consequently, FBW7 is frequently mutated in human cancers (Jardim et al., 2014), as loss of FBW7 activates positive cell cycle regulators (Welcker and Clurman, 2008) and downregulates the expression of negative cell cycle regulators such as CDH1 (Lau et al., 2013; Pucci et al., 2000).