Changes in AS of ATP5C1, DCLK2, and MAP3K4 rewire interactions with a “Hypertrophic cardiomyopathy” pathway, and of CACNA1C, TPM3, and ITGB1 rewire interactions with the “Diabetic cardiomyopathy” pathway. The gene discussed is DCLK2; the disease is diabetic cardiomyopathy.