AKT1 and cardiovascular disorder: All three are related to cardiovascular disease and endothelial cells: “leukocyte transendothelial migration,” “RAC1 GTPase cycle,” and “RHOA GTPase cycle.” Endothelial cells can be severely disturbed in cardiac disease [53], and chronic stimulation of RHO or RAC signaling is involved in inflammatory diseases, hypertension, or decompensated heart failure [54].