CCL2 and myocardial infarction: For example, pyridostigmine bromide (PYR) can reduce the chemotactic factor CCL2/7 (C-C chemokine ligand), leading to a reduction in cardiac MHC-IIhiCCR2+ macrophage infiltration and increases in the numbers of M2 macrophages and Treg cells in mouse models of myocardial infarction (MI) (19–21).