In a rat model of porcine serum-induced liver fibrosis, AS-IV (2, 4 mg/kg) significantly reduced serum levels of hyaluronic acid, type III procollagen and TGF-β1, as well as hepatic TGF-β and hydroxyproline content (Liu et al., 2009). Here, TGFB1 is linked to Hepatic fibrosis.