ex DC., Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, Tripterygium wilfordii Hook.f., Coptis chinensis Franch., and their derivatives, have been shown to modulate the AMPK/SIRT1/mTOR autophagy pathway in DKD. The gene discussed is SIRT1; the disease is diabetic kidney disease.