In vitro studies corroborate this, demonstrating that β-Asarone upregulates LC3, Beclin-1, PINK1, and Parkin, while downregulating p62 expression in PC12 cells within AD models, increasing autophagic flux and mitigating Aβ aggregation (Wang et al., 2019). The gene discussed is MAP1LC3A; the disease is Alzheimer disease.