While WMH is considered an early feature of Alzheimer’s disease in studies of autosomal dominant Alzheimer’s disease mutation carriers13 our findings align with those from the Mayo Clinic which showed that, despite the coexistence of WMH and amyloid or tau in similar brain regions, there was no temporal relationship in their onsets or progression, suggesting independent mechanisms.17 The gene discussed is MAPT; the disease is Alzheimer disease.