Data from the Montalcino Aortic Consortium, an international registry of patients with heritable thoracic aortic disease, revealed ns-TAAD patients with a TGFBR1 mutation have a greater aortic risk, particularly if they are female, but a TGFBR2 mutation was associated with smaller aortic root diameter prior to or at the time of type A aortic dissection[61]. Here, TGFBR1 is linked to Ascending aortic dissection.