Importantly, they also found that 19% of individuals carrying a variant in SMAD3 experienced extra-thoracic disease - abdominal aortic aneurysm, iliac artery aneurysm, or intracranial aneurysm - which argues for screening for other aneurysmal sites in those carrying a SMAD3 variant[62]. Here, SMAD3 is linked to Dilatation of the cerebral artery.