INS and type 2 diabetes mellitus: These hypotheses were based on the previously reported effects of insulin on vasodilation and vasoconstriction (Baron et al., 1995; Cleland et al., 1999; Miller et al., 2002) and works that identified impaired vasodilation of arterioles in T2D (Frisbee et al., 2019; Haak et al., 1992; Miller et al., 2002; Takahashi et al., 1990).