Routine laboratory tests of anaphylaxis are up to now limited to the evaluation of serum total tryptase levels; further research is still needed to be able to evaluate other biomarkers of anaphylaxis such as PAF, chymase, carboxypeptidase A£, dipeptidyl peptidase, basogranulin, and CCL-2; the half-life of these biomarkers is challenging for their routine measurement in real life (21). The gene discussed is CCL2; the disease is anaphylaxis.