OMG and myeloid sarcoma: Within the context of immune-mediated mechanisms, demyelination, central to the pathology and progression of MS, is mostly initiated by B-cells, which damage myelin and oligodendrocytes through multiple pathways, including the production of myelin oligodendrocyte glycoprotein and myelin basic protein production, T-cells activation, oligoclonal bands secretion, and amplification of other inflammatory cascades.