The results showed that anti-β2GPI-D1 has a high specificity of 95% (95% CI 88%-98%) and a moderate sensitivity of 52% (95% CI 46%-58%), indicating that anti-β2GPI-D1 is a potential marker for diagnosing APS, particularly beneficial in confirming the diagnosis due to its high specificity. This evidence concerns the gene APOH and autoimmune polyendocrinopathy.