MAPT and amyloidosis: Smailovic et al. (2018) reported a negative correlation between CSF Aβ42 levels and slow-frequency power (θ and δ), as well as between p-tau and t-tau levels and fast-frequency power (α and β). Reduced CSF Aβ42 and elevated p-tau and t-tau were also associated with decreased α and β GFS levels. Mechanistically, amyloid pathology may cause slow-frequency interference through the cholinergic system, while tau pathology, akin to neuronal loss and degeneration, affects fast frequencies in the cortex (Smailovic and Jelic, 2019).